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27102

Sigma-Aldrich

Citronensäure Monohydrat

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

Synonym(e):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Lineare Formel:
HOC(COOH)(CH2COOH)2 · H2O
CAS-Nummer:
5949-29-1
Molekulargewicht:
210.14
Beilstein:
4018641
EG-Nummer:
201-069-1
MDL-Nummer:
MFCD00149972
UNSPSC-Code:
12352100
PubChem Substanz-ID:
57648219
NACRES:
NA.21

Qualität

puriss.
meets analytical specification of Ph. Eur., BP, USP, E330

Assay

99.5-100.5% (based on anhydrous substance)

Form

grit

Verunreinigungen

residual solvents, complies
≤0.0005% heavy metals (as Pb)
7.5-8.8% water (Karl Fischer)

Glührückstand

≤0.05% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

Anionenspuren

chloride (Cl-): ≤50 mg/kg
oxalate (as oxalic acid): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

Kationenspuren

As: ≤1 mg/kg
Ca: ≤200 mg/kg
Cu: ≤10 mg/kg
Fe: ≤10 mg/kg
Hg: ≤1 mg/kg
Pb: ≤1 mg/kg
Zn: ≤10 mg/kg

Eignung

complies for appearance of solution
complies for identity (IR)
complies for reaction against H2SO4

SMILES String

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChIKey

YASYEJJMZJALEJ-UHFFFAOYSA-N

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Allgemeine Beschreibung

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1

Anwendung

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319,H335

Gefahreneinstufungen

Eye Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

345.0 °F - closed cup

Flammpunkt (°C)

173.9 °C - closed cup

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number
BCCK3277
BCCH5300
BCCG2090
BCCD2310
BCBT5913

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Zitronensäure ACS reagent, ≥99.5%

Sigma-Aldrich

251275

Zitronensäure

Citronensäure, wasserfrei Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1071

Citronensäure, wasserfrei

Natriumcitrat, dreibasisch Dihydrat puriss. p.a., ACS reagent, ≥99.0% (NT)

Sigma-Aldrich

71405

Natriumcitrat, dreibasisch Dihydrat

Zitronensäure anhydrous for synthesis

Sigma-Aldrich

8.18707

Zitronensäure

S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
Enthalpy of solution of oxalic, succinic, adipic, maleic, malic, tartaric, and citric acids, oxalic acid dihydrate, and citric acid monohydrate in water at 298.15K.
Apelblat A.
The Journal of Chemical Thermodynamics, 18(4), 351-357 (1986)
Carolina Ganss et al.
PloS one, 10(6), e0123889-e0123889 (2015-06-16)
For preventing erosive wear in dentine, coating with adhesives has been suggested as an alternative to fluoridation. However, clinical studies have revealed limited efficacy. As there is first evidence that Sn(2+) increases bond strength of the adhesive Clearfil SE (Kuraray)
Kristine Opsvik Wikene et al.
Drug development and industrial pharmacy, 41(6), 969-977 (2014-05-21)
Bacterial resistance to antibiotics is increasing and alternative antibacterial treatments like antimicrobial photodynamic therapy (aPDT) are needed. Curcumin is under investigation as a potential photosensitizer in aPDT. The purpose of this study was to develop rapidly dissolving formulations of curcumin
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