MABS45

Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2

clone CPTC-ANXA1-2, from mouse

• Synonym(e): annexin A1, chromobindin-9, annexin I (lipocortin I), Lipocortin I, calpactin-2, Calpactin II, annexin-1, Phospholipase A2 inhibitory protein, Annexin I, Calpactin-2, Annexin-13, Chromobindin-9
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• Klon: CPTC-ANXA1-2, monoclonal
• application: IHC; WB
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable; western blot: suitable

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: CPTC-ANXA1-2, monoclonal
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• Isotyp: IgG2aκ
• NCBI-Hinterlegungsnummer: NP_000691
• UniProt-Hinterlegungsnummer: P04083
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ANXA1(301)

Beschreibung

Allgemeine Beschreibung

Annexin A1 (ANXA1) is a calcium and phospholipid binding protein almost entirely restricted to microglia in the CNS. During the peripheral inflammatory response, Annexin A1 is instrumental in the phagocytosis of apoptotic leukocytes. Annexin A1 restores the ability of microglia to differentiate between apoptotic and non-apoptotic cells during inflammatory activation. Current research is geared towards using Annexin A1 as a therapeutic target in neuroinflammation. Annexin A1 has also been shown to be influential in cancer development and proliferation.

Immunogen

Full length recombinant protein corresponding to human Annexin A1.

Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
GPCR-, cAMP/cGMP- & kalziumabhängige Signalübertragung

Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (http://antibodies.cancer.gov/antibodies/detail/CPTC-ANXA1-2)

This Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 is validated for use in WB, IH for the detection of Annexin A1.

Qualität

Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Annexin A1 on 10 µg of K562 cell lysate.

Zielbeschreibung

~ 39 kDa observed

Physikalische Form

Protein G

Format: Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
K562 cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable