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Key Documents

MABS1966

Sigma-Aldrich

Anti-PEG Antibody, clone 6.3

clone 6.3, from mouse

Synonym(e):

Polyethylene Glycol

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

6.3, monoclonal

Speziesreaktivität (Voraussage durch Homologie)

all

Verpackung

antibody small pack of 25 μg

Methode(n)

ELISA: suitable

Isotyp

IgG1κ

Posttranslationale Modifikation Target

unmodified

Allgemeine Beschreibung

Polyethylene glycols (PEG) are non-toxic, uncharged, hydrophilic long chain polymers with a big exclusion volume in aqueous solution. The covalent attachment of PEG is commonly employed to modify proteins and drugs that can increase their bioavailability and reduce immunogenicity and proteolytic degradation. Clone 6.3 displays high affinity and binds the PEG backbone and can be employed as a detection antibody for the quantification of PEG. It binds to a smaller epitope of the PEG backbone when compared to other antibodies. Since it binds to a smaller PEG epitope (~750 Da), it is not compatible with detergents that contain an ethylene oxide backbone, such as Tween 20. Instead 0.05% CHAPS is a more suitable detergent when using this antibody.

Spezifität

Clone 6.3 specifically detects proteins conjugated with polyethylene glycol (PEG).

Immunogen

PEG-conjugated to E.coli beta-glucuronidase.

Anwendung

Research Category
Zelluläre Signaltransduktion
Anti-PEG, clone 6.3, Cat. No. MABS1966, is a mouse monoclonal antibody that detects PEG-conjugated proteins and it hs been tested for use in ELISA.
ELISA Analysis: A representative lot detected PEG in ELISA applications (Tung, H.Y., et. al. (2015). Mol Cancer Ther. 14(6):1317-26).

Qualität

Evaluated by ELISA in Immobilized PEG (10K-PEG, 3K-PEG, and 2K-mPEG).

ELISA Analysis: 5 µg/mL of Immobilized PEG (10K-PEG, 3K-PEG, and 2K-mPEG) were detected with this antibody.

Physikalische Form

Protein A purified
Format: Purified
Purified mouse monoclonal antibody IgG1 in PBS with 0.04% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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