MABN323

Anti-Ermin Antibody, clone 160

clone 160, from mouse

• Synonym(e): Ermin, Juxtanodin
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 160, monoclonal
• Speziesreaktivität: mouse, rat
• Methode(n): immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• Isotyp: IgG2aκ
• NCBI-Hinterlegungsnummer: NP_084248
• UniProt-Hinterlegungsnummer: Q5EBJ4
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Ermn(77767)

Beschreibung

Allgemeine Beschreibung

Ermin is also known as Juxtanodin (JN). Ermin is involved in cytoskeletal rearrangements during myelinogenesis and in the maintenance and stability of the myelin sheath in adults. Ermin is also thought to be important in oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the plasticity of related structures in the mature CNS. Ermin is exclusively expressed by oligodendrocytes in the brain and spinal cord, where it appears in the late stages of myelination, and in the mature nerves, it is localized in the outer cytoplasmic lip of the myelin sheath and the paranodal loops.

Immunogen

Recombinant protein corresponding to mouse Ermin.

Anwendung

Research Category
Neurowissenschaft

Research Sub Category
Entwicklungsneurowissenschaft

Anti-Ermin Antibody, clone 160 is a highly specific mouse monoclonal antibody, that targets Ermin & has been tested in western blotting, ICC & IHC.

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Ermin in mouse wild type sagittal brain sections, and demonstrated a loss of signal in mouse OL-ablated sagittal brain sections (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-762).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Ermin in certain mouse brain and optic nerve sections (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-762).

Qualität

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Ermin in 10 µg of mouse brain tissue lysate.

Zielbeschreibung

~42 kDa observed. The calculated molecular weight of this protein is 32 kDa; however, it has been observed at ~42 kDa (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-76.).

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Mouse brain tissue lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable