MABF216

Anti-Microsialin/CD68 Antibody, clone 9

clone 9, 1 mg/mL, from rat

• Synonym(e): Macrosialin, CD68
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rat
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 9, monoclonal
• Speziesreaktivität: mouse
• Konzentration: 1 mg/mL
• Methode(n): flow cytometry: suitable
• Isotyp: IgG2aκ
• NCBI-Hinterlegungsnummer: NP_033983
• UniProt-Hinterlegungsnummer: P31996
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Cd68(12514)

Beschreibung

Allgemeine Beschreibung

Microsialin/CD68, also known as Macrosialin, Gp110, CD_antigen 68, or CD68, and encoded by the gene CD68, is a membrane protein expressed in macrophages (and other cells) that appears to play a role in the phagocytic activities of tissue macrophages both in intracellular lysosomal metabolism but also in extracellular cell to cell interactions and cell pathogen interactions. Microsialin binds to tissue and organ-specific lectins or selectins mediating homing of macrophage subsets to particular sites. Also, rapid recirculation of Microsialin from the endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selection-bearing substrates or other cells. Microsialin is expressed in blood monocytes and tissue macrophages primarily but is also found expressed in lymphocytes, fibroblasts and endothelial cells so it is not an exclusive marker for macrophages. Also Microsialin is expressed on many tumor cells which seem to allow the tumor cells to attach to selectins on the vascular endothelium facilitating their dissemination to secondary sites.

Immunogen

Recombinant protein corresponding to mouse Microsialin/CD68.

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Immunoglobuline & Immunologie

Anti-Microsialin/CD68 Antibody, clone 9 is an antibody against Microsialin/CD68 for use in flow cytometry.

Physikalische Form

Protein G Purified

Format: Purified

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable