MAB5326C3
Anti-Nestin Antibody, clone 10C2, Cy3 conjugate
clone 10C2, from mouse, CY3 conjugate
Synonym(e):
Nestin10c2, NES, Nbla00170, FLJ21841
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Konjugat
CY3 conjugate
Antikörperform
purified antibody
Antikörper-Produkttyp
primary antibodies
Klon
10C2, monoclonal
Speziesreaktivität
human
Methode(n)
immunocytochemistry: suitable
Isotyp
IgG1
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... NES(10763)
Allgemeine Beschreibung
Nestin, a large intermediate filament protein (class Type VI) expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18. Nestin is thought to be a reasonable neuronal marker; however, recent studies have found nestin expression in other cell types such as endothelial cells {Folia Biologica, 44(5):155, 1998}. Nestin identifies the most primitive neuroepithelium but also identifies many other embryonic tissues, so it is not specific for CNS. Nestin expression is seen in almost all GBMs (Glioblastoma mulitformes) and many melanomas (both primary and metastatic) but not in any metastatic carcinoma.
Spezifität
This antibody recognizes human Nestin. Antibody is not reactive with rat or mouse Nestin protein.
Immunogen
Fusion protein corresponding to human Nestin.
Anwendung
Research Category
Stammzellforschung
Neurowissenschaft
Stammzellforschung
Neurowissenschaft
Research Sub Category
Neurofilament & Neuronen-Stoffwechsel
Neuronen- & Gliamarker
Neurofilament & Neuronen-Stoffwechsel
Neuronen- & Gliamarker
Detect Nestin using this Anti-Nestin Antibody, clone 10C2, Cy3 conjugate validated for use in ICC.
Qualität
Evaluated by Immunocytochemistry in human RNcell CX neural stem cells (SCC007). Immunocytochemsitry Analysis: A 1:100 dilution of this antibody detected Nestin in human RNcell CX neural stem cells (SCC007).
Zielbeschreibung
The uncojugated parent antibody (Catalog No. MAB5326) has an observed MW at 200-220 kDa
Physikalische Form
Protein A purified
Purified mouse monoclonal IgG1 conjugated to Cy3 in PBS with 0.1% sodium azide and 15mg/ml BSA.
Lagerung und Haltbarkeit
Maintain refrigerated at 2-8ºC protected from light in undiluted aliquots for up to 6 months from date of receipt.
Hinweis zur Analyse
Control
RNcell CX neural stem cells (SCC007).
RNcell CX neural stem cells (SCC007).
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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C A Messam et al.
Experimental neurology, 161(2), 585-596 (2000-02-25)
The presence of the intermediate filament protein nestin has been the predominant marker used to describe stem and progenitor cells in the mammalian CNS. In this study, a 998-bp fragment in the 3' region of the nestin mRNA was cloned
Jinte Middeldorp et al.
Development (Cambridge, England), 137(2), 313-321 (2009-12-31)
A subpopulation of glial fibrillary acidic protein (GFAP)-expressing cells located along the length of the lateral ventricles in the subventricular zone (SVZ) have been identified as the multipotent neural stem cells of the adult mammalian brain. We have previously found
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(5), 1551-1561 (2006-02-03)
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