MAB3319
Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6
clone 114-6G6, Chemicon®, from mouse
Synonym(e):
MT1-MMP
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Antikörperform
purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
114-6G6, monoclonal
Speziesreaktivität
human
Darf nicht reagieren mit
pig, rat, mouse
Hersteller/Markenname
Chemicon®
Methode(n)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
Isotyp
IgG1κ
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... MMP14(4323)
Verwandte Kategorien
Spezifität
The antibody specifically reacts with human MT1-MMP. This is a purified mouse monoclonal antibody to an oligopeptide of REVPYAYIREGHEK (residue 160-173) on human membrane-type 1 matrix metalloproteinase (human MT1-MMP) and does not react with mouse or rat. However, this sequence is identical in mouse and rat MT1-MMP. For unknown reasons this antibody does not react on westerns to CC1043.
Immunogen
Epitope: catalytic domain
Anwendung
Research Category
Zellstruktur
Zellstruktur
Research Sub Category
MMPs & TIMPs
MMPs & TIMPs
Immunoblotting: 8-20 μg/mL. 66+60kDa (Ueno et al., 1997)
Immunohistochemistry on paraffin-embedded tissue sections, use at 20 μg/mL concentration (see Ueno et al., 1997; Nakamura et al., 1999). Requires periodate-lysine-paraformaldehyde fixative (Namura et al., 1999) for 18-24 hrs. at 4°C.
EIA Optimal working dilutions must be determined by end user.
Immunohistochemistry on paraffin-embedded tissue sections, use at 20 μg/mL concentration (see Ueno et al., 1997; Nakamura et al., 1999). Requires periodate-lysine-paraformaldehyde fixative (Namura et al., 1999) for 18-24 hrs. at 4°C.
EIA Optimal working dilutions must be determined by end user.
This Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6 is validated for use in ELISA, WB, IH(P) for the detection of MMP-14.
Physikalische Form
Format: Purified
Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.
Lagerung und Haltbarkeit
Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Sonstige Hinweise
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Rechtliche Hinweise
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Manufactured by Daiichi Fine Chemical Co., Ltd
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Empfehlung
Produkt-Nr.
Beschreibung
Preisangaben
Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
Katarzyna Starska, Olga Stasikowska, Marek Lukomski, Iwona Lewy-Trenda
Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego null
Yongping Li et al.
American journal of translational research, 7(1), 120-127 (2015-03-11)
Membrane type 1 matrix metalloproteinase (MT1-MMP) has been demonstrated to play an important role in tumor progression. The aim of the present study was to analyze the expression of MT1-MMP in breast cancer and its correlation with clinicopathologic characteristics, including
Bo-Ra Son et al.
Stem cells (Dayton, Ohio), 24(5), 1254-1264 (2006-01-18)
Human mesenchymal stem cells (MSCs) are increasingly being considered in cell-based therapeutic strategies for regeneration of various organs/tissues. However, the signals required for their homing and recruitment to injured sites are not yet fully understood. Because stromal-derived factor (SDF)-1 and
Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation.
Mu?oz-Najar, UM; Neurath, KM; Vumbaca, F; Claffey, KP
Oncogene null
Dae-Il Chang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 23(12), 1408-1419 (2003-12-10)
During focal cerebral ischemia, matrix metalloproteinase-2 (MMP-2) can contribute to the loss of microvessel integrity within ischemic regions by degrading the basal lamina. MMP-2 is secreted in latent form (pro-MMP-2), but the activation of pro-MMP-2 in the ischemic territory has
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