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Allgemeine Beschreibung
Antipain is known for regulating the number of chromosomal aberrations caused by the S-phase-dependent alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine. It can also diminish the nuclear binding of the estrogen-receptor complex in MCF-7 breast tumor cells.
Anwendung
Antipain has been used in microfluidic chip assay.
Biochem./physiol. Wirkung
Inhibitor Type: Protease Inhibitors
Qualität
pH 1% aqueous solution: 5.2
Physikalische Form
Lyophilized no preservatives.
Properties: Soluble in H2O, methanol and DMSO (Stock solution: 10 mM). Stable at -20° C.
Mechanism of action: Formation of a hemicetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase.
Inhibition spectrum: Inhibits papain, trypsin and plasmin to a lesser extent. More specific for papain and trypsin than leupeptin. The inhibitory potency of antipain is 100-fold higher than that of elastatinal.
Pale yellow powder; material is isolated from cultured media of microorganisms. As with many of these compounds, they are too inherently unstable to allow for high standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities.
Properties: Soluble in H2O, methanol and DMSO (Stock solution: 10 mM). Stable at -20° C.
Mechanism of action: Formation of a hemicetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase.
Inhibition spectrum: Inhibits papain, trypsin and plasmin to a lesser extent. More specific for papain and trypsin than leupeptin. The inhibitory potency of antipain is 100-fold higher than that of elastatinal.
Pale yellow powder; material is isolated from cultured media of microorganisms. As with many of these compounds, they are too inherently unstable to allow for high standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities.
Lagerung und Haltbarkeit
Maintain dry at -20ºC for up to 18 months. Store reconstituted product in aliquots at -20ºC for up to 9 months. Do not thaw and refreeze.
Rechtliche Hinweise
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Structure of antipain, a new Sakaguchi-positive product of streptomyces.
S Umezawa et al.
The Journal of antibiotics, 25(4), 267-270 (1972-04-01)
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