ABT52

Anti-phospho-Peak Antibody (Tyr665)

from rabbit, purified by affinity chromatography

• Synonym(e): Pseudopodium-enriched atypical kinase 1, Sugen kinase 269, Tyrosine-protein kinase SgK269
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Speziesreaktivität (Voraussage durch Homologie): porcine (based on 100% sequence homology), rat (based on 100% sequence homology), orangutan (Sumatran; based on 100% sequence homology), mouse (based on 100% sequence homology)
• Methode(n): dot blot: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_079052
• UniProt-Hinterlegungsnummer: Q9H792
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: phosphorylation (pTyr665)
• Angaben zum Gen: human ... PEAK1(79834)

Beschreibung

Allgemeine Beschreibung

Pseudopodium-enriched atypical kinase 1 (Peak1; KIAA2002, or sgk269) is a ubiquitous non-receptor tyrosine kinase that belongs to the NFK3 family. It interacts with actin filaments via its N-terminal actin-targeting region. It also modulates the activity of multiple cytoskeletal regulatory proteins such as paxillin, p130Cas, Erk, and Crk; and mediates cell proliferation and migration via the Ras/Raf/Erk and Src-p130Cas-Crk-Paxillin pathways. Peak1 may play an important role in the progression of tumors.

Spezifität

This antibody recognizes Peak phosphorylated at Tyr665.

Immunogen

Epitope: Phosphorylated Tyr665

KLH-conjugated linear peptide corresponding to human Peak phosphorylated at Tyr665.

Anwendung

This phospho-Peak antibody is validated for use in WB & Dot Blot for the detection of the phospho-Peak protein.

Western Blot Analysis: A representative lot was used by an independent laboratory in 293T cells transfected with wildtype GFP-Peak. (Dr. Richard Klemke, University of California-San Diego.)

Qualität

Evaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.

Dot Blot (Specificity) Analysis: A representative lot blocked phospho-Peak (Tyr665) in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.

Zielbeschreibung

220 kDa calculated

Hinweis zur Analyse

Control
Modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable