ABC97

Anti-Birc7/LIVIN Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, KIAP, Livin, Melanoma inhibitor of apoptosis protein, ML-IAP, RING finger protein 50
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Speziesreaktivität (Voraussage durch Homologie): rhesus macaque (based on 100% sequence homology)
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_647478
• UniProt-Hinterlegungsnummer: Q96CA5
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... BIRC7(79444)

Beschreibung

Allgemeine Beschreibung

Livin, also known as “baculoviral IAP repeat-containing protein 7” (Birc7) and "KIAP," is a member of the IAP (inhibitors of apoptosis) family of proteins characterized by highly conserved baculoviral IAP repeats (BIR). In addition, Livin contains one RING-type zinc finger domain. Livin has been detected in the heart, placental, lung, lymph node, ovary, spleen, and in various types of solid tumors. It may suppress apoptosis induced by TNF, viral infection, drugs, and growth factor withdrawal, by inhibiting caspase activity (caspase 3, 7, and 9) and activating a MAPK/JUN pathway. Paradoxically, Livin may also function as a pro-apoptic factor in a truncated form (tLivin) that is cleaved by caspase 3 from the full-length protein. The pro-apoptotic effects of Livin may depend on its RING domain. Livin may play a role in non-Hodgkin lymphoma.

Spezifität

Other homologies: Rat, Mouse, and Bovine (93% sequence homology).

This antibody recognizes the BIR repeat region of Birc7/LIVIN.

Immunogen

Epitope: BIR repeat region

KLH-conjugated linear peptide corresponding to the BIR repeat region of human Birc7/LIVIN.

Anwendung

Research Category
Apoptose & Krebs

Research Sub Category
Apoptose - Weiterführende Produkte

Anti-Birc7/LIVIN detects levels of Birc7/LIVIN proteins & has been published & validated for use in WB.

Qualität

Evaluated by Western Blot in human spleen tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Birc7/LIVIN in 10 µg of human spleen tissue lysate.

Zielbeschreibung

~39 kDa, ~32 kDa observed. Two isoforms at 32 kDa and 30 kDa are known to exist. This protein has been observed at ~39 kDa (alpha) and ~37 kDa (beta) due to post translational modification (Nachmias, B., et al. (2007). Apoptosis. 12(7):1129-1142.).

Physikalische Form

Affinity purified

Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Human spleen tissue lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable