ABC347

Anti-Fn14 Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): Fn14 Antibody, Fibroblast growth factor-inducible 14, TNFRSF12, TWEAK-R, FGF-inducible 14
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Methode(n): immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProt-Hinterlegungsnummer: Q9NP84
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TNFRSF12A(51330)

Beschreibung

Allgemeine Beschreibung

Fibroblast growth factor 14 (FN14) is a member of the TNF receptor superfamily. FN14 is a receptor for TNFSF12/TWEAK and promotes angiogenesis and the proliferation of endothelial cells. Experiments have shown that FN14 binds to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Additionally, FN14 is a weak inducer of apoptosis in some cell types and may modulate cellular adhesion to matrix proteins. FN14 is suggested to induce liver regeneration and is highly expressed in hepatocellular carcinomas. Furthermore, TWEAK induces liver progenitor cell proliferation, suggesting FN14 may play a role in hepatocyte growth control and liver neoplasia. FN14 is highly expressed in heart, placenta and kidney. Intermediate expression of FN14 has been recorded in lung, skeletal muscle and pancreas.

Immunogen

KLH-conjugated Fc-tagged protein corresponding to human Fn14.

Anwendung

Research Category
Apoptose & Krebs

Research Sub Category
Apoptose - Weiterführende Produkte

Anti-Fn14 Antibody is a highly specific rabbit polyclonal antibody, that targets Fibroblast growth factor 14 & has been tested in western blotting, IHC & Immunofluorescence.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected Fn14 in human liver tissue lysate.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected Fn14 in human liver tissue.

Qualität

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 4 µg/mL of this antibody detected Fn14 in 15 µg of HepG2 cell lysate.

Zielbeschreibung

~34 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~10 kDa and ~14 kDa

Physikalische Form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
HepG2 cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable