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AB9042

Sigma-Aldrich

Anti-Brain Derived Neurotrophic Factor Antibody, pro

Chemicon®, from chicken

Synonym(e):

proBDNF, pro BDNF

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

chicken

Qualitätsniveau

100

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Speziesreaktivität

mouse, rat, human

Hersteller/Markenname

Chemicon®

Methode(n)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NM_001709.3
NM_170731.3
NM_170732.3
NM_170733.2
NM_170734.2
NM_170735.4

UniProt-Hinterlegungsnummer

P23560

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... BDNF(627)

Spezifität

Reacts with proBDNF. Does not recognize mature BDNF isoforms.

Immunogen

Fusion protein from mouse proBDNF containing only the prodomain region.

Anwendung

Anti-Brain Derived Neurotrophic Factor Antibody, pro detects level of Brain Derived Neurotrophic Factor & has been published & validated for use in IP, WB, IH.
Western blot: 1:500-1:1,000. Reacts with bands of 30 kD and 28 kD.Immunohistochemistry: 1:100-1:250 on frozen sections.

Immunohistochemistry: 1:100-1:200

Immunoprecipitation: 1:100

Optimal working dilutions must be determined by the end user.

Physikalische Form

Chicken immunoglobulin. Liquid.
Format: Semi-Purified

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons.
Chen, Zhe-Yu, et al.
The Journal of Neuroscience, 24, 4401-4411 (2004)
Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice.
Papaleo, F; Silverman, JL; Aney, J; Tian, Q; Barkan, CL; Chadman, KK; Crawley, JN
Learning & Memory null
Michael S Beattie et al.
Neuron, 36(3), 375-386 (2002-11-01)
The neurotrophin receptor p75 is induced by various injuries to the nervous system, but its role after injury has remained unclear. Here, we report that p75 is required for the death of oligodendrocytes following spinal cord injury, and its action
Heejung Chun et al.
Experimental neurobiology, 27(3), 155-170 (2018-07-20)
Astrocytes are the most abundant cell type in the brain and they make close contacts with neurons and blood vessels. They respond dynamically to various environmental stimuli and change their morphological and functional properties. Both physiological and pathological stimuli can
Anna R Taylor et al.
Developmental neurobiology, 72(5), 699-712 (2011-08-13)
Motoneurons (MN) as well as most neuronal populations undergo a temporally and spatially specific period of programmed cell death (PCD). Several factors have been considered to regulate the survival of MNs during this period, including availability of muscle-derived trophic support
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