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AB3639

Sigma-Aldrich

Anti-Endonuclease G Antibody

Chemicon®, from rabbit

Synonym(e):

EndoG

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

mouse, rat, human

Hersteller/Markenname

Chemicon®

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NM_004435.2

UniProt-Hinterlegungsnummer

Q14249

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ENDOG(2021)
mouse ... Endog(13804)
rat ... Endog(362100)

Spezifität

Recognizes Endonuclease G (EndoG), a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. EndoG is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2).

Immunogen

Synthetic peptide corresponding to amino acids 55 to 70 of human EndoG (GGPRGPGELAKYGLP).

Anwendung

Research Category
Apoptose & Krebs
Research Sub Category
Apoptose - Weiterführende Produkte
Anti-Endonuclease G Antibody is an antibody against Endonuclease G for use in WB.
Western blotting (1-2μg/mL)

Optimal working dilutions must be determined by the end user.

Physikalische Form

Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

Lagerung und Haltbarkeit

Maintain at 2-8ºC for 12 months.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

L Y Li et al.
Nature, 412(6842), 95-99 (2001-07-14)
Nucleosomal fragmentation of DNA is a hallmark of apoptosis (programmed cell death), and results from the activation of nucleases in cells undergoing apoptosis. One such nuclease, DNA fragmentation factor (DFF, a caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD)), is capable
Shuangping Zhao et al.
Journal of neuroscience research, 88(8), 1727-1737 (2010-01-16)
We have shown that generalized seizures produce necrotic neurons with caspase-independent nuclear pyknosis and DNA fragmentation. In this study, we determined the time course of translocation of mitochondrial cytochrome c, apoptosis-inducing factor, endonuclease G, lysosomal cathepsins B and D, and
Caspase-independent pathways of hair cell death induced by kanamycin in vivo
Jiang, H, et al
Cell Death and Differentiation, 13, 20-30 (2006)
Po-Yuan Chen et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 718320-718320 (2012-08-25)
Phenethyl isothiocyanate (PEITC), an effective anticancer and chemopreventive agent, has been reported to inhibit cancer cell growth through cell-cycle arrest and induction of apoptotic events in various human cancer cells models. However, whether PEITC inhibits human oral squamous cell carcinoma
Mitochondrial endonuclease G is important for apoptosis in C. elegans.
Parrish, J, et al.
Nature, 412, 90-94 (2001)
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