8.55094

Trichloroacetimidate Wang resin

Novabiochem^®

• Synonym(e): Trichloroacetimidate Wang resin
• CAS-Nummer: 89238-99-3
• MDL-Nummer: MFCD00134547
• UNSPSC-Code: 12352101
• NACRES: NA.22
• Form: beads

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Form: beads
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Lagertemp.: 2-8°C
• InChI: 1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3
• InChIKey: TYHGKLBJBHACOI-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A highly versatile reagent for the solid phase immobilization of alcohols ^[1,2,3]; carboxylic, phosphonic and sulfonic acids ^[4]; thiols and thioacids ^[4]; and phenols ^[5]. In contrast to the analogous bromide resin which is loaded under basic conditions, derivatization of this support is achieved under acidic conditions, making it compatible with base-sensitive compounds such as Fmoc-amino alcohols.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] S. Hanessian & X. Fang (1998) Tetrahedron Lett., 39, 733.
^[2] A. Bianco, et al. (2000) J. Comb. Chem., 2, 681.
^[3] A. Kamal, et al. (2002) Tetrahedron Lett., 43, 2103.
^[4] C. W. Phoon, et al. (1998) Tetrahedron Lett., 39, 7959.
^[5] A. Kamal, et al. (2001) Tetrahedron Lett., 42, 6969.

Verlinkung

Replaces: 01-64-0314

Hinweis zur Analyse

Farbe (visuell): schwach gelb bis beige
Aussehen der Substanz (visuell): Kügelchen
Beladung (Elementaranalyse aus Schwefel nach Derivatisierung mit Schwefelessigsäure): 0.60 - 1.20 mmol/g
Aufquellvolumen (in DMF): chargenspezifischer Wert
Die Polymermatrix ist Copoly (Styrol-1% DVB), 100 - 200 mesh

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable