8.55035

DFPE polystyrene

Novabiochem^®

• Synonym(e): 2-(3,5-Dimethoxy-4-formylphenoxy)ethyl polystyrene
• UNSPSC-Code: 13111023

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Form: beads
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: aldehyde
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

This resin is prepared under conditions optimized to minimize styrene formation during attachment of the linker to the functionalized ethylpolystyrene support. This high substitution, coupled with the lack of amide bonds and potentially acid-sensitive benzylic linkages, makes this support the preferred choice of SPOS of secondary sulfonamides and carboxamides. Applications of FMPE include aminofurazanopyrazines ^[1] and peptide agonists for human orphan receptor BRS-3 ^[2].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins Literature references

Literature references

^[1] B. Dörner & P. White in ′Peptides 1998, Proc. 25th European Peptide Symposium′, S. Bajusz & F. Hudecz (Eds), Budapest, Akadémiai Kiadó, 1999, pp. 90.
^[2] M. Grimstrup & F. Zaragoza (2002) Eur. J. Org. Chem., 2953.
^[3] K. J. Jensen, et al. (1998) J. Am. Chem. Soc., 120, 5441.
^[4] M. del Fresno, et al. (1998) Tetrahedron Lett., 39, 2639.
^[5] N. S. Gray, et al. (1997) Tetrahedron Lett., 38, 1161.
^[6] J. Alsina, et al. (1999) Chem. Eur. J., 5, 2787.
^[7] J. F. Tolborg & K. J. Jensen (2000) Chem. Commun., 147.
^[8] A. E. Fenwick, et al. (2001) Bioorg. Med. Chem. Lett., 11, 195.
^[9] J. Giovannoni, et al. (2001) Tetrahedron Lett., 42, 5389.
^[10] J. T. Bork, et al. (2003) Org. Lett., 5, 117.
^[11] C. P. Holmes, Paper ORGN 383 presented at the 213th National Meeting of the American Chemical Society, San Francisco, 1997.
^[12] C. Pégurier, et al. (2000) Bioorg. Med. Chem., 8,163.
^[13] T. F. Herpin, et al. (2000) J. Comb. Chem., 2, 513.

Verlinkung

Replaces: 01-64-0360

Hinweis zur Analyse

Farbe (visuell): weiß bis gelb bis beige
Aussehen der Substanz (visuell): Kügelchen
Beladung (Elementaranalyse aus Schwefel nach Derivatisierung mit Tosylhydrazid): 0.50 - 1.10 mmol/g
Aufquellvolumen (in DMF): chargenspezifischer Wert
Die Polymermatrix ist Copoly (Styrol-1 % DVB), 100 - 200 mesh

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable