8.55013

NovaSyn^®TG Sieber resin

Novabiochem^®

• Synonym(e): 9-Fmoc-amino-xanthen-3-yloxy TG resin
• UNSPSC-Code: 13111023
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: NovaSyn^® TG; Novabiochem^®
• Form: beads
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: amine
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

NovaSyn TG Sieber resin consists of 130 μm NovaSyn TG bromo resin derivatized with Sieber′s xanhydrylamine linker ^[1,2]. This resin is ideal for the Fmoc SPPS of partially protected peptide amide fragments. Cleavage from this support is effected by treatment with 1% TFA in DCM, conditions that leave most standard side-chain protecting groups intact. This resin can be reductively alkylated and used to prepare secondary carboxamides ^[3]. It can also be employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester ^[4].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] P. Sieber (1987) Tetrahedron Lett., 28, 2107.
^[2] C. Somlai, et al. in ′Peptides 1992, Proc.22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 198.
^[3] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 1475.
^[4] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 589.

Verlinkung

Replaces: 01-64-0092

Hinweis zur Analyse

Farbe (visuell): hellgelb bis gelb bis beige
Aussehen der Substanz (visuell): Kügelchen
Beladung (Photometrische Bestimmung des Fmoc-Chromophors nach Abspaltung mit DBU/DMF): 0.10 - 0.25 mmol/g
Aufquellvolumen (in DMF): chargenspezifischer Wert
Die Polymermatrix ist ein NovaSyn TG Harz (130µm)

Rechtliche Hinweise

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable