8.52345

Fmoc-Gla(OtBu)2-OH

Novabiochem^®

• Synonym(e): Fmoc-γ-carboxy-Glu(OtBu) ₂-OH
• Empirische Formel (Hill-System): C₂₉H₃₅NO₈
• CAS-Nummer: 111662-64-7
• Molekulargewicht: 525.59
• UNSPSC-Code: 12352209
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Form: solid
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: carboxylic acid
• Lagertemp.: 2-8°C
• InChI: 1S/C29H35NO8/c1-28(2,3)37-25(33)21(26(34)38-29(4,5)6)15-23(24(31)32)30-27(35)36-16-22-19-13-9-7-11-17(19)18-12-8-10-14-20(18)22/h7-14,21-23H,15-16H2,1-6H3,(H,30,35)(H,31,32)/t23-/m0/s1
• InChIKey: XJRUHYXXHXECDI-QHCPKHFHSA-N

Beschreibung

Allgemeine Beschreibung

Fmoc-Gla(OtBu)2-OH is a building block for the introduction of γ-carboxyglutamic acid (Gla). γ -Carboxylation of glutamic acid is a rare post-translational modification that occurs in blood coagulation factors and in some snake and cone snail venoms ^[1].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] P. K. Bandyopadhyay (2002) Proc. Natl. Acad. Sci. USA, 99, 1264 .

Hinweis zur Analyse

Colour (visual): white to slight yellow to slight red
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.
European Union for cosmetic colour additives.

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable