8.52186

Fmoc-Asp(OtBu)-Ser(psiMe,Mepro)-OH

≥97.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonym(e): Fmoc-Asp(OtBu)-Ser(psiMe,Mepro)-OH
• Empirische Formel (Hill-System): C₂₉H₃₄N₂O₈
• CAS-Nummer: 955048-92-7
• Molekulargewicht: 538.59
• UNSPSC-Code: 12352209
• NACRES: NA.22

Eigenschaften

• product name: Fmoc-Asp(OtBu)-Ser(psiMe,Mepro)-OH, Novabiochem^®
• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Assay: ≥97% (TLC); ≥97.0% (HPLC)
• Form: powder
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: hydroxyl
• Lagertemp.: 2-8°C
• InChI: 1S/C29H35N3O7/c1-28(2,3)31-24(33)14-22(25(34)32-23(26(35)36)16-39-29(32,4)5)30-27(37)38-15-21-19-12-8-6-10-17(19)18-11-7-9-13-20(18)21/h6-13,21-23H,14-16H2,1-5H3,(H,30,37)(H,31,33)(H,35,36)
• InChIKey: XGFUSEUVGFMDEN-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Asp-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Verlinkung

Replaces: 05-20-1011

Hinweis zur Analyse

Farbe (visuell): weiß bis schwach gelb bis beige
Aussehen der Substanz (visuell): Pulver
Identität (IR): entspricht
Optische Drehung α 25/D (c=1 in CH₂Cl₂): -53.5 - -46.5 °
Reinheit (DC(CMA2)): ≥ 97 %
Reinheit (DC(157A)): ≥ 97 %
Gehalt (HPLC, Fl.%): ≥ 97.0 % (a/a)
Verunreinigungen einzeln (HPLC, Fl.%): ≤ 1.00 % (a/a)
Acetat (IC): ≤ 0.1 %
Ethylacetat (HS-GC): ≤ 2.0 %
DC-Bedingungen gemäß den Angaben unseres Hauptkataloges

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable