8.52120

Fmoc-Gln(Dmcp)-OH

Novabiochem^®

• Synonym(e): N-α-Fmoc-N-γ-(1-cyclopropyl-1-methylethyl)-L-glutamine
• Empirische Formel (Hill-System): C₂₆H₃₀N₂O₅
• CAS-Nummer: 172947-20-5
• Molekulargewicht: 450.53
• UNSPSC-Code: 12352209

Eigenschaften

• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Assay: ≥90.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• Form: solid
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: amide
• Lagertemp.: 15-25°C

Beschreibung

Allgemeine Beschreibung

A superior derivative to Fmoc-Gln(Trt)-OH for the synthesis of Gln-containing peptides by Fmoc SPPS. Fmoc-Gln(Dmcp)-OH is more soluble in DMF than Fmoc-Gln(Trt)-OH, thereby facilitating coupling reactions at higher concentration. Cleavage of the Dmcp group is rapid, even when the residue is located at the N-terminus of a peptide. Coupling of Dmcp-protected derivatives is faster than that of the corresponding hindered Trt derivatives. Dmcp-protected peptides have enhanced solubility.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] L. A. Carpino, et al. (1995) J. Org. Chem., 60, 7718.

Verlinkung

Replaces: 04-12-1292

Hinweis zur Analyse

DC-Bedingungen gemäß den Angaben unseres Hauptkataloges
Gehalt (acidimetrisch): ≥ 90.0 %
Gehalt (HPLC, Fl.%): ≥ 98.0 % (a/a)
Wasser (K. F.): ≤ 1.00 %
Identität (IR): entspricht
Löslichkeit (1 mmol in 2 ml DMF): entspricht
Farbe (visuell): entspricht
Aussehen der Substanz (visuell): entspricht
Reinheit (DC(CMA2)): ≥ 98 %
Enantiomerenreinheit: ≥ 99.5 % (a/a)

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable