8.52094

Fmoc-Lys(Mmt)-OH

≥95.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonym(e): N-α-Fmoc-N-ε-4-methoxytrityl-L-lysine
• Empirische Formel (Hill-System): C₄₁H₄₀N₂O₅
• CAS-Nummer: 159857-60-0
• Molekulargewicht: 640.77
• UNSPSC-Code: 12352209
• NACRES: NA.22

Eigenschaften

• product name: Fmoc-Lys(Mmt)-OH, Novabiochem^®
• Qualitätsniveau: 200
• Produktlinie: Novabiochem^®
• Assay: ≥80.0% (acidimetric); ≥95% (TLC); ≥95.0% (HPLC)
• Form: powder
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: amine
• Lagertemp.: 2-8°C
• InChI: 1S/C41H40N2O5/c1-47-32-25-23-31(24-26-32)41(29-14-4-2-5-15-29,30-16-6-3-7-17-30)42-27-13-12-22-38(39(44)45)43-40(46)48-28-37-35-20-10-8-18-33(35)34-19-9-11-21-36(34)37/h2-11,14-21,23-26,37-38,42H,12-13,22,27-28H2,1H3,(H,43,46)(H,44,45)/t38-/m0/s1
• InChIKey: CTYHQVFFQRDJSN-LHEWISCISA-N

Beschreibung

Allgemeine Beschreibung

An excellent derivative for the synthesis by Fmoc SPPS of branched peptides and peptides modified at the lysine side-chain ^[1], and for the construction of templates and multifunctionalized resins for combinatorial synthesis.The side-chain Mmt group can be selectively removed in the same manner as Mtt with 1% TFA in DCM ^[2,3,4] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) ^[5]. Alternatively, it can be removed under milder conditions with AcOH/TFE/DCM (1:2:7) ^[1], leaving Mtt intact.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] S. Matysiak, et al. (1998) Tetrahedron Lett., 39, 1733.
^[2] K. Barlos, et al., C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 283.
^[3] A. Aletras, et al. (1995) Int. J. Peptide Protein Res., 45, 488.
^[4] L. Bourel, et al. (2000) J. Peptide Sci., 6, 264.
^[5] K. Barlos, personal communication.

Anwendung

• Synthesis and evaluation of antifungal peptoid derivatives against Cryptococcus neoformans: For drug discovery chemists, this research highlights the use of Fmoc-Lys(Mmt)-OH in synthesizing peptoid derivatives with potential antifungal properties, demonstrating the compound′s utility in developing new antimicrobial agents (M Wassom, 2022).

Verlinkung

Replaces: 04-12-1232

Hinweis zur Analyse

Farbe (visuell): weiß bis schwach gelb bis beige
Aussehen der Substanz (visuell): Pulver
Identität (IR): entspricht
Enantiomerenreinheit: ≥ 99.0 % (a/a)
Reinheit (DC(0009)): ≥ 95 %
Gehalt (HPLC, Fl.%): ≥ 95.0 % (a/a)
Gehalt (acidimetrisch): ≥ 80.0 %
Wasser (K. F.): ≤ 2.0 %
DC-Bedingungen gemäß den Angaben unseres Hauptkataloges.
Das Produkt ist mit bis zu 20% Diisopropylether stabilisiert .

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable