567300

SKF-525A, Hydrochloride

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.

• Synonym(e): SKF-525A, Hydrochloride, Proadifen
• Empirische Formel (Hill-System): C₂₃H₃₁NO₂ · xHCl
• CAS-Nummer: 62-68-0
• Molekulargewicht: 353.50 (free base basis)
• MDL-Nummer: MFCD00055151
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (TLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Farbe: white
• Löslichkeit: water: 20 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H
• InChIKey: FHIKZROVIDCMJA-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels (IC₅₀ = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels. Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
nNOS

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 90 µM against neuronal nitric oxide synthase

Warnhinweis

Toxicity: Harmful (C)

Rekonstituierung

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

Sonstige Hinweise

Hecker, M., et al. 1994. J. Neurochem. 62, 1524.
Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol.252, 117.
Khan, S., et al. 1993. Biochem. Pharmacol.45, 439.
Boeynaems, J.M., et al. 1986. Prostaglandins32, 145.
Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther.198, 347.
Grasdalen, J., et al. 1975. FEBS Lett.60, 240.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable