554718

REV-ERBα Antagonist, SR8278

The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.

• Synonym(e): REV-ERBα Antagonist, SR8278, SR8278SR 8278
• Empirische Formel (Hill-System): C₁₈H₁₉NO₃S₂
• CAS-Nummer: 101910-24-1
• Molekulargewicht: 361.48
• MDL-Nummer: MFCD00211150
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: >95% (HPLC)
• Form: gum; solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white to yellow-brown
• Löslichkeit: DMSO: 25 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• SMILES String: n1c2c(ccc1COc3cc(ccc3)C(O)CCCCC)cccc2
• InChIKey: JRLOEMCOOZSCQP-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC₅₀ = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC₅₀ = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Regulatory Review (Z)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

Sonstige Hinweise

Kojetin, D., et al. 2010, Chem Bio in press

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable