530050-M

PRIMA-1

A cell-permeable quinuclidinone analog with antitumor properties.

• Synonym(e): PRIMA-1, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
• Empirische Formel (Hill-System): C₉H₁₅NO₃
• CAS-Nummer: 5608-24-2
• Molekulargewicht: 185.22
• MDL-Nummer: MFCD04974196
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (NMR)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Farbe: off-white
• Löslichkeit: water: 2 mg/mL
• Lagertemp.: 2-8°C
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChIKey: RFBVBRVVOPAAFS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.

A cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.

Biochem./physiol. Wirkung

Primary Target
Restores biochemical and biological function to mutant p53

Warnhinweis

Toxicity: Standard Handling (A)

Sonstige Hinweise

Bykov, V.J., et al. 2002. Nat. Med.8, 282.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H334
• P-Sätze: P261 - P264 - P270 - P284 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Resp. Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable