481984

Nifuroxazide

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity.

• Synonym(e): Nifuroxazide, 5-Nitro-2-furaldehyde- p-hydroxybenzoylhydrazone, 5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
• Empirische Formel (Hill-System): C₁₂H₉N₃O₅
• CAS-Nummer: 965-52-6
• Molekulargewicht: 275.22
• MDL-Nummer: MFCD00079482
• UNSPSC-Code: 12352125

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: bright yellow
• Löslichkeit: DMSO: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
• InChIKey: YCWSUKQGVSGXJO-NTUHNPAUSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC₅₀ = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-_κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC₅₀ = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC₅₀ = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-_κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC₅₀ = 10 µM against tyr⁷⁰⁵ of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser⁷²⁷ phosphorylation of STAT3.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Sonstige Hinweise

Nelson, E.A., et al. 2008. Blood112, 5095.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3