475874-M

MK571, Sodium Salt

A selective, competitive antagonist of leukotriene D4 (LTD4) (K_i = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).

• Synonym(e): MK571, Sodium Salt, L 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt
• Empirische Formel (Hill-System): C₂₆H₂₆ClN₂O₃S₂ · Na
• CAS-Nummer: 115104-28-4
• Molekulargewicht: 537.07
• UNSPSC-Code: 12352211

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥90% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated
• Farbe: off-white
• Löslichkeit: DMSO: 10 mg/mL; water: 200 mg/mL
• Lagertemp.: −20°C
• InChI: 1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+
• InChIKey: AXUZQJFHDNNPFG-UXBLZVDNSA-N

Beschreibung

Allgemeine Beschreibung

A selective, competitive antagonist of leukotriene D₄ (LTD₄) (K_i = 2.1 nM for inhibition of [³H]LTD₄ binding to human lung membranes). Also inhibits multidrug resistance-associated protein 1 (MRP1).

A selective, competitive antagonist of leukotriene D₄ (LTD₄) receptor (K_i = 2.1 nM for inhibition of [³H]LTD₄ binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).

Biochem./physiol. Wirkung

Primary Target
Antagonist of leukotriene D4 (LTD4)

Target K_i: 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.

Sonstige Hinweise

Olson, D.P., et al. 2001. Cytometry46, 105.
Van der Kolk, D.M., et al. 1998. Clin. Cancer Res.4, 1727.
Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol.67, 17.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable