444264

MMP Inhibitor III

The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(e): MMP Inhibitor III
• Empirische Formel (Hill-System): C₁₉H₂₉N₃O₄
• CAS-Nummer: 927827-98-3
• Molekulargewicht: 363.45
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥90% (TLC)
• Form: lyophilized solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated
• Farbe: off-white
• Löslichkeit: DMSO: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases (supplied as a racemic mixture). Inhibits MMP-1 (IC₅₀ = 7.4 nM), MMP-2 (IC₅₀ = 2.3 nM), MMP-3 (IC₅₀ = 135 nM), MMP-7 (IC₅₀ = 10-100 nM), and MMP-13 (IC₅₀ = 1-10 nM).

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
MMP-1

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 7.4 nM, 2.3 nM, 135 nM, 10-100 nM, 1-10 nM, against MMP-1, MMP-2, MMP-3, MMP-7, and MMP-13, respectively

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months (-20°C).

Sonstige Hinweise

Covington, M.D., et al. 2006, Am. J. Physiol. Renal. Physiol.290, F43.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable