420361

KMO Inhibitor II, JM6

The KMO Inhibitor II, JM6 controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonym(e): KMO Inhibitor II, JM6, Kynurenine-3-Monooxygenase Inhibitor II, JM6, Kynurenine-3-Hydroxylase Inhibitor II, JM6, 2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, KMO Inhibitor I, Ro 61-8048 Prodrug
• Empirische Formel (Hill-System): C₂₃H₂₆N₄O₆S₂
• Molekulargewicht: 518.61
• UNSPSC-Code: 12352200
• NACRES: NA.28

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: powder
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: 5 mg/mL
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

An orally bioavailable in-vivo prodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC₅₀ = 4 µM) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Campesan, S., et al. 2011. Chem. Biol.21, 961.
Zwilling, D., et al. 2011. Cell145, 863.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable