377980

Hispidin

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC₅₀ = 2 µM).

• Synonym(e): Hispidin, 6-(3,4-Dihydroxystyrl)-4-hydroxy-2-pyrone
• Empirische Formel (Hill-System): C₁₃H₁₀O₅
• CAS-Nummer: 555-55-5
• Molekulargewicht: 246.22
• MDL-Nummer: MFCD01866972
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥90% (HPLC)
• Form: powder
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,15-17H/b3-1+
• InChIKey: QISBNGLMCHHHFG-HNQUOIGGSA-N

Beschreibung

Allgemeine Beschreibung

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKC_β; IC₅₀ = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.

A potent, cell permeable, and reversible inhibitor of protein kinase C_β isoform (PKC_β; IC₅₀ = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
PKCβ

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2 µM against PKCβ

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Gonindard, C., et al. 1997. Cell Biol. Toxicol. 13, 141.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available