343781-M

ω-Conotoxin GVIA, Conus geographus

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca²⁺ channels and of neurotransmitter release at neuronal synapses.

• Synonym(e): ω-Conotoxin GVIA, Conus geographus, ω-CgTx GVIA
• Empirische Formel (Hill-System): C₁₂₀H₁₈₂N₃₈O₄₃S₆
• CAS-Nummer: 106375-28-4
• Molekulargewicht: 3037.35
• MDL-Nummer: MFCD00076620
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: lyophilized
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Löslichkeit: water: 250 μg/mL; aqueous buffer: soluble
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca²⁺ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC₅₀ = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).

Biochem./physiol. Wirkung

Primary Target
Voltage-activated N-type Ca2+ channels

Target IC₅₀: 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors

Warnhinweis

Toxicity: Highly Toxic (H)

Sequenz

H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Lalo, U.V., et al. 2001. Brain Res. Bull.54, 507.
Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
Olivera, B.M., et al. 1991. J. Biol. Chem.266, 22067.
Protti, D.A., et al. 1991. Brain Res.557, 336.
Werth, J.L., et al. 1991. Mol. Pharmacol.40, 742.
Koyano, K., et al. 1987. Eur. J. Pharmacol.135, 337.
Abe, T., et al. 1986. Neurosci. Lett.71, 203.

Rechtliche Hinweise

Not available for sale outside of the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable