219675

CFTR Inhibitor II, GlyH-101

InSolution, ≥97%, potent, selective and reversible open-channel blocker of CFTR

• Synonym(e): InSolution CFTR Inhibitor II, GlyH-101, N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
• Empirische Formel (Hill-System): C₁₉H₁₅Br₂N₃O₃
• CAS-Nummer: 328541-79-3
• Molekulargewicht: 493.15
• UNSPSC-Code: 12352200
• NACRES: NA.28

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: liquid
• Wirksamkeit: 4.3 μM K_i
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• InChI: 1S/C19H15Br2N3O3/c20-15-8-13(18(26)17(21)19(15)27)9-23-24-16(25)10-22-14-6-5-11-3-1-2-4-12(11)7-14/h1-9,22,26-27H,10H2,(H,24,25)/b23-9+
• InChIKey: RMBDLOATEPYBSI-NUGSKGIGSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; K_i = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl^- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl^- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl^- currents, and is effective in nasal and intestinal epithelia in vivo.

Biochem./physiol. Wirkung

Cell permeable: yes

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Irritant (B)

Physikalische Form

A 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.

Rekonstituierung

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): 188.6 °F - closed cup - (refers to pure substance)
• Flammpunkt (°C): 87 °C - closed cup - (refers to pure substance)