14-787-M

PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.

• UNSPSC-Code: 12352200
• eCl@ss: 32160405
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100; 300
• Rekombinant: expressed in baculovirus infected Sf21 cells
• Mol-Gew.: M_w 129 kDa (p110α; H1047R); M_w 83.6 kDa (p85α)
• Hersteller/Markenname: Upstate^®
• Methode(n): activity assay: suitable (kinase)
• NCBI-Hinterlegungsnummer: NM_006218.2
• UniProt-Hinterlegungsnummer: P42336
• Angaben zum Gen: mouse ... PIK3CA(18706)

Beschreibung

Allgemeine Beschreibung

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R αand untagged, recombinant, full length mouse p85α.

Product Source: Coexpressed by baculovirus in Sf21 insect cells.

The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.

Anwendung

Research Category
Entzündung & Immunologie

Biochem./physiol. Wirkung

Protein Target: PI3Kα/p85α

Target Sub-Family: PI3K/PI4K

Verpackung

Also available in 250μg size --call for pricing and availability and reference catalog number 14-787M when ordering the 250μg size.

Physikalische Form

Ni²⁺/NTA-agarose

Lagerung und Haltbarkeit

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

Sonstige Hinweise

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H317
• P-Sätze: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Gefahreneinstufungen: Skin Sens. 1
• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable