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Key Documents

14-629-M

Sigma-Aldrich

JAK3 Protein, active, 10 µg

Active, N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end, for use in Kinase Assays.

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32

Biologische Quelle

human

Qualitätsniveau

Rekombinant

expressed in baculovirus infected Sf21 cells

Produktlinie

Upstate®

Spezifische Aktivität

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

Mol-Gew.

Mw 39.9 kDa

Aufgereinigt durch

(Ni2+/NTA-agarose)

Speziesreaktivität

human

Hersteller/Markenname

Upstate®

Methode(n)

activity assay: suitable (kinase)

Hinterlegungsnummer

 (FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. )
NM_000215.2

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Allgemeine Beschreibung

N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end

Anwendung

Research Category
Entzündung & Immunologie

Biochem./physiol. Wirkung

Protein Target: JAK3
Target Sub-Family: TK

Verpackung

Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-629M when ordering the 250 µg size.

Qualität

routinely evaluated by phosphorylation of 500μM JAK3tide (Catalog # 12-547)

Zielbeschreibung

JAK3

Physikalische Form

Ni2+/NTA-agarose

Lagerung und Haltbarkeit

6 months at -70°C

Sonstige Hinweise

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Skin Sens. 1

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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B A Witthuhn et al.
Nature, 370(6485), 153-157 (1994-07-14)
Many cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies have shown that one or more of the Janus kinase family
J A Johnston et al.
Nature, 370(6485), 151-153 (1994-07-14)
Interleukin-2 is an autocrine growth factor for T cells which also activates other cells including B cells and natural killer cells. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event

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