09-158

Anti-ALK7 Antibody

Upstate^®, from rabbit

• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: rat, mouse, human
• Hersteller/Markenname: Upstate^®
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_660302
• UniProt-Hinterlegungsnummer: Q8NER5
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ACVR1C(130399) ; mouse ... Acvr1C(269275) ; rat ... Acvr1C(245921)

Beschreibung

Allgemeine Beschreibung

ALK7 (ACVR1C activin A receptor, type IC; ACVRLK4) is a transmembrane type IC receptor serine kinase for activin or activin-like ligands. Activins, are dimeric factors that belong to the TGF-superfamily of signaling proteins. Activins signal through the hetrodimeric complex that includes two type I (I and IB) and two type II (II and IIB) receptors. The type I receptors (i.e. ALK7) contains a Ser/Thr kinase domain in its cytoplasmic domain that is essential for signaling, while the type II are receptors are essential for ligand binding (Harrison, 2004 & Gray, 2000). Receptor activation involves ligand binding to the promiscuous type II receptor that is known to bind to many ligands. This leads to the recruitment of ALK7 and the formation of a stable heterodimer that results in the phosphorylation and activation of ALK7.

Spezifität

Recognizes ALK7

Immunogen

Synthetic peptide designed against the N-terminal region of human ALK7

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
Cytokine & Cytokin-Rezeptoren

Entwicklungsabhängige Signalübertragung

Wachstumsfaktoren & -rezeptoren

Anti-ALK7 Antibody is an antibody against ALK7 for use in WB.

Qualität

Routinely evaluated by western blot on either human or rat brain lysate

Zielbeschreibung

55 kDa

Physikalische Form

Affinity purified using immunogen

Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable