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Key Documents

07-810

Sigma-Aldrich

Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody

Upstate®, from rabbit

Synonym(e):

c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

mouse, human

Speziesreaktivität (Voraussage durch Homologie)

rat (based on 100% sequence homology)

Hersteller/Markenname

Upstate®

Methode(n)

immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

NM_000245.2

UniProt-Hinterlegungsnummer

P08581

Versandbedingung

dry ice

Posttranslationale Modifikation Target

phosphorylation (pTyr1230/pTyr1234/pTyr1235)

Angaben zum Gen

human ... MET(4233)
mouse ... Met(17295)
rat ... Met(24553)

Spezifität

Recognizes Met phosphorylated on both Tyr1234/Tyr1235 and Tyr1230/Tyr1234/Tyr1235.

Immunogen

Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-c-Met (Tyr1230/Tyr1234/Tyr1235)

Anwendung

Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody is an antibody against phospho-Met (Tyr1230/Tyr1234/Tyr1235) for use in IC, IF & WB.
Immunoblot Analysis: A 1:1000 dilution of this lot detected phospho-Met (Tyr1230/Tyr1234/Tyr1235) in RIPA lysate of HGF treated 293T cells.

Qualität

Routinely evaluated by immunoblot.

Zielbeschreibung

155 kDa

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Federica Chiara et al.
The Journal of biological chemistry, 278(31), 29352-29358 (2003-05-15)
The met oncogene, encoding the high affinity hepatocyte growth factor receptor, is the only known gene inherited in human cancer that is invariably associated with somatic duplication of the mutant locus. Intriguingly, mutated Met requires ligand stimulation in order to
P Longati et al.
Oncogene, 9(1), 49-57 (1994-01-01)
The tyrosine kinase encoded by the MET proto-oncogene (p190MET) is the receptor for Hepatocyte Growth Factor/Scatter Factor (HGF/SF). Previous work has shown that autophosphorylation of p190MET enhances its enzymatic activity and that the major phosphorylation site is Tyr1235, located in
c-Met modulates RPE migratory response to laser-induced retinal injury.
Kasaoka, M; Ma, J; Lashkari, K
Testing null
A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells
Hov, H?kon, et al
Clinical cancer research : an official journal of the American Association for Cancer Research, 10, 6686-6694 (2004)
Helena L Palka et al.
The Journal of biological chemistry, 278(8), 5728-5735 (2002-12-12)
The receptor protein-tyrosine phosphatase (PTP) DEP-1 (CD148/PTP-eta) has been implicated in the regulation of cell growth, differentiation, and transformation, and most recently has been identified as a potential tumor suppressor gene mutated in colon, lung, and breast cancers. We have
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