07-1492

Anti-Calcineurin Aα Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): NFAT transcription complex cytosolic component, nuclear factor of activated T-cells, cytoplasmic,, calcineurin-dependent 1, nuclear factor of activated T-cells, cytosolic component 1
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: rat, mouse, human
• Speziesreaktivität (Voraussage durch Homologie): mammals (based on 100% sequence homology)
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_000935.1
• UniProt-Hinterlegungsnummer: Q08209
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PPP3CA(5530) ; mouse ... Ppp3Ca(19055) ; rat ... Ppp3Ca(24674)

Beschreibung

Allgemeine Beschreibung

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal transduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling. The Aα form of calcineurin is a major catalytic subunit gene isoform of calcineurin in most tissues that allows differentiation of Aα from the Aβ and Aγ isoforms.

Spezifität

This antibody recognizes the Aα form of calcineurin.

Immunogen

KLH-conjugagted synthetic peptide corresponding to Calcineurin Aα.

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
GPCR-, cAMP/cGMP- & kalziumabhängige Signalübertragung

This Anti-Calcineurin Aα Antibody is validated for use in WB for the detection of Calcineurin Aα.

Qualität

Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.

Zielbeschreibung

58 kDa

Verlinkung

Replaces: AB1696

Physikalische Form

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.

Lagerung und Haltbarkeit

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Hinweis zur Analyse

Control
Mouse brain lysate

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable