06-342
Anti-JAK3 Antibody
serum, Upstate®
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
serum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Speziesreaktivität
mouse
Hersteller/Markenname
Upstate®
Methode(n)
western blot: suitable
Isotyp
IgG
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
mouse ... Jak3(16453)
Spezifität
: Recognizes murine JAK3, Mr 125kDa and JAK3 degradation products, Mr 95-120kDa. The antiserum shows very poor immunoreactivity for human JAK3. No immunoreaction was noted with immuno-precipitated mouse JAK1 and JAK2
This antibody has been tested on several human cell lines including A431, Hela, Jurkat, and HEK293 cells. The antiserum shows very poor immunoreactivity for human JAK3
Immunogen
peptide corresponding to residues 934-952 (RDELCVAGAQLYACQDPAI) of murine JAK3. The immunizing peptide sequence shares 16/19 amino acids with rat JAK3, but contains an amino acid insertion, which may block cross-reactivity. The immunizing peptide shares 12/19 amino acids with human JAK3.
Anwendung
Anti-JAK3 Antibody is an antibody against JAK3 for use in WB.
Qualität
routinely evaluated by immunoblot on lysate from a mouse cytotoxic T lymphocyte cell line (CTLL)
Zielbeschreibung
125 kDa
Physikalische Form
antiserum containing 0.05% sodium azide
Lagerung und Haltbarkeit
2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery, centrifuge the original vial after thawing and prior to removing the cap.
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Analysenzertifikate (COA)
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Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.
Tsujino, S; Di Santo, JP; Takaoka, A; McKernan, TL; Noguchi, S; Taya, C; Yonekawa et al.
Proceedings of the National Academy of Sciences of the USA null
Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.
Chen, X H, et al.
The Journal of Biological Chemistry, 272, 6556-6560 (1997)
R L Palmer-Crocker et al.
The Journal of clinical investigation, 98(3), 604-609 (1996-08-01)
IL-4 and IL-13 each act on human endothelial cells (ECs) to induce expression of vascular cell adhesion molecule-1. On hematopoietic cells. IL-4 responses may be mediated either through a pathway involving gc, the common signaling subunit of the IL-2, IL-4
T Yin et al.
The Journal of biological chemistry, 272(2), 1032-1037 (1997-01-10)
Interactions between SHP-2 phosphotyrosine phosphatase and JAK tyrosine kinases have recently been implicated in cytokine signal transduction. However, the molecular basis of these interactions is not well understood. In this study, we demonstrate that SHP-2 is tyrosine-phosphorylated by and associated
Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
Yu, C. L. and Burakoff, S. J.
The Journal of Biological Chemistry, 272, 14017-14020 (1997)
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