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Key Documents

06-1049

Sigma-Aldrich

Anti-Axin-1 Antibody

from rabbit, purified by affinity chromatography

Synonym(e):

Axin-1, Axis inhibition protein 1, hAxin

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

mouse, human

Methode(n)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NP_003493

UniProt-Hinterlegungsnummer

O15169

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

mouse ... Axin1(12005)

Allgemeine Beschreibung

Axin-1 is a beta-catenin destruction complex scaffold protein and a transcription factor of the Wnt signaling pathway. Variation in the Wnt signaling pathway has been associated with the formation of some primary human cancers. Axin-1 mutation has been linked to oral squamous cell carcinoma. Axin-1 binds to GSK3alpha and activates the Wnt signaling pathway which is shown to be associated with growth and development of cells. Axin-1 has also been implicated in Alzheimer′s disease.

Immunogen

KLH-conjugated linear peptide corresponding to human Axin-1.

Anwendung

Anti-Axin-1 Antibody is an antibody against Axin-1 for use in WB, IC, IH.
Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Axin-1 in A431 and HeLa cells.

Immunohistochemistry Analysis: 1:1,000 dilution from a representative lot detected Axin-1 in human kidney and human skin tissues.

Qualität

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Axin-1 on 10 µg of HEK293 cell lysate.

Zielbeschreibung

~110 kDa observed. An uncharacterized band appears at ~40 and 45 kDa in some lysates.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Shiwei Zhou et al.
Pharmaceutics, 13(3) (2021-04-04)
Genetic evidence has indicated that β-catenin plays a vital role in glucose and lipid metabolism. Here, we investigated whether pyrvinium, an anthelmintic agent previously reported as a down-regulator of cellular β-catenin levels, conferred any metabolic advantages in treatment of metabolic
Yiwei Li et al.
Cell stem cell, 28(1), 63-78 (2020-10-15)
Enormous amounts of essential intracellular events are crowdedly packed inside picoliter-sized cellular space. However, the significance of the physical properties of cells remains underappreciated because of a lack of evidence of how they affect cellular functionalities. Here, we show that

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