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Key Documents

05-726

Sigma-Aldrich

Anti-53BP1 Antibody, clone BP13

clone BP13, Upstate®, from mouse

Synonym(e):

Anti-53BP1, Anti-p202, Anti-p53BP1

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

BP13, monoclonal

Speziesreaktivität

human

Hersteller/Markenname

Upstate®

Methode(n)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_005657.1

UniProt-Hinterlegungsnummer

Q12888

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... TP53BP1(7158)

Spezifität

53BP1

Immunogen

Mix of three GST fusion proteins corresponding to residues 1-337, 338-671, and 1331-1664, respectively, of human 53BP1

Anwendung

Research Category
Epigenetik & nukleäre Funktionen
Research Sub Category
Transkriptionsfaktoren
Detect 53BP1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.
Does not cross-react with mouse.

Qualität

routinely evaluated by immunoblot on lysates from HeLa cells

Zielbeschreibung

~250kDa

Physikalische Form

Protein G Purified
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified

Lagerung und Haltbarkeit

2 years at -20°C

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Quantitative analysis of DNA-damage response factors after sequential ion microirradiation.
Christoph Greubel, Volker Hable, Guido A Drexler, Andreas Hauptner, Steffen Dietzel et al.
Radiation and Environmental Biophysics null
I M Ward et al.
The Journal of biological chemistry, 276(51), 47759-47762 (2001-10-24)
H2AX, a member of the histone H2A family, is rapidly phosphorylated in response to ionizing radiation. This phosphorylation, at an evolutionary conserved C-terminal phosphatidylinositol 3-OH-kinase-related kinase (PI3KK) motif, is thought to be critical for recognition and repair of DNA double
Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile.
Fay Minty, Johanna K Thurlow, Paul R Harrison, E Kenneth Parkinson
Experimental Cell Research null
Guanghua Du et al.
Radiation research, 176(6), 706-715 (2011-07-30)
High-linear energy transfer (LET) ion irradiation of cell nuclei induces complex and severe DNA lesions, and foci of repair proteins are formed densely along the ion trajectory. To efficiently discriminate the densely distributed/overlapping foci along the ion trajectory, a focus
Ji-Hwan Park et al.
Experimental & molecular medicine, 53(6), 1092-1108 (2021-07-01)
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This diminished reaction may be explained by the disrupted transmission of nuclear signals. However, this hypothesis requires more evidence before it can be accepted as a mechanism of cellular
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