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BQ-788, Sodium Salt

• Synonym(e): BQ-788, Sodium Salt, N- cis-2,6-Dimethylpiperidinocarbonyl-L-γ-MeLeu-D-Trp(MeOCO)-D-Nle-OH, Na
• Empirische Formel (Hill-System): C₃₄H₅₀N₅NaO₇
• Molekulargewicht: 663.78
• UNSPSC-Code: 12352200
• NACRES: NA.28

Eigenschaften

• Assay: ≥95% (HPLC)
• Qualitätsniveau: 100
• Form: lyophilized solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated
• Farbe: white to off-white
• Löslichkeit: 0.01% NH₄OH: 1 mg/mL; DMSO: 2 mg/mL; methanol: water (3:1): 2 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A highly selective and competitive ETB receptor antagonist (IC₅₀ = 1.2 nM).

Highly selective ET_B-receptor antagonist (IC₅₀ = 1.2 nM).

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
ETB-receptor antagonist

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1.2 nM as ETB-receptor antagonist

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). DMSO and Methano:H₂O stock solutions are stable for up to 2 months at -20°C.

Sonstige Hinweise

Okada, M., and Nishikibe, M. 2002. Cardiovasc. Drug Reviews20, 53.
Taniai, H., et al. 2001. Hepatology33, 894.
Fukuroda, T., et al. 1994. Biochem. Biophys. Res. Commun.199, 1461.
Ishikawa, K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 4892.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable