890899C

DODMA

Avanti Research^™ - A Croda Brand

• Synonym(e): 1,2-Dioleyloxy-3-dimethylaminopropane
• Empirische Formel (Hill-System): C₄₁H₈₁NO₂
• CAS-Nummer: 104162-47-2
• Molekulargewicht: 620.09
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Assay: >99% (TLC)
• Form: chloroform solution
• Verpackung: pkg of 1 × 4 mL (890899C-100MG); pkg of 5 × 4 mL (890899C-500MG)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Konzentration: 25 mg/mL in chloroform
• Anwendung(en): advanced drug delivery
• Lipid-Typ: cationic lipids; transfection
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CN(C)CC(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC
• InChI: 1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3
• InChIKey: GLGLUQVVDHRLQK-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is an ionizable cationic lipid. DODMA possesses one double bond in each hydrocarbon tail with tertiary amine group and has a pKa of 7.0.

Anwendung

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem./physiol. Wirkung

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

Verpackung

5 mL Clear Glass Sealed Ampule (890899C-100MG)
5 × 5 mL Clear Glass Sealed Ampule (890899C-500MG)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H302,H315,H319,H331,H336,H351,H361d,H372
• P-Sätze: P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable