870320P

N-palmitoyl homocysteine (PHC)

Avanti Research^™ - A Croda Brand 870320P, powder

• Synonym(e): N-palmitoyl homocysteine (ammonium salt)
• Empirische Formel (Hill-System): C₂₀H₄₂N₂O₃S
• CAS-Nummer: 474942-73-9
• Molekulargewicht: 390.62
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 25 mg (870320P-25mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 870320P
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [O-]C(C(NC(CCCCCCCCCCCCCCC)=O)CCS)=O.[NH4+]
• InChI: 1S/C20H39NO3S.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)21-18(16-17-25)20(23)24;/h18,25H,2-17H2,1H3,(H,21,22)(H,23,24);1H3
• InChIKey: WUXWCXRWTBPUKZ-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

N-palmitoyl homocysteine (PHC) is a pH sensitive head group modified lipid.

Anwendung

N-palmitoyl homocysteine (PHC) has been used in the synthesis of micelle-encapsulated temozolomide (TMZ) and targeted rapamycin micelles (TRaM).

Biochem./physiol. Wirkung

Liposomes containing pH-sensitive molecules facilitate site-specific drug release in response to the change of pH in the surrounding serum. They deliver drugs or gene fragments into the cytoplasm through the endocytotic pathway. Unlike plain liposomes, pH-sensitive liposomes effectively protect drugs and other encapsulated contents such as enzymes, plasmids, proteins and peptides from being potentially degraded at the lysosomal level. They have a wide range of clinical applications such as a carrier of potent drugs for cancer, pulmonary and infectious diseases, a vaccine adjuvant and a vehicle for contrasting agents during imaging. In addition, pH-sensitive liposomes also facilitate the transport of nucleic acids during gene therapy. DOPE liposomes containing PHC deliver their contents at the early endosome.

Verpackung

5 mL Amber Glass Screw Cap Vial (870320P-25mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3