857128P

18:0 Lyso PA

Avanti Research^™ - A Croda Brand

• Synonym(e): 1-octadecanoyl-sn-glycero-3-phosphate (sodium salt); stearoyl lysophosphatidic acid; PA(18:0/0:0); 18:0 LPA; s-LPA; 110680
• Empirische Formel (Hill-System): C₂₁H₄₂O₇PNa
• CAS-Nummer: 325465-92-7
• Molekulargewicht: 460.52
• UNSPSC-Code: 51191904
• NACRES: NA.25

Eigenschaften

• Beschreibung: 1-stearoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
• Assay: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• Form: powder
• Verpackung: pkg of 1 × 25 mg (857128P-25mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Lipid-Typ: cardiolipins; phospholipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

Beschreibung

Allgemeine Beschreibung

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA), a bioactive phospholipid is seen at a low level in plasma (~100nM). It is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells. 18:0 Lyso PA has stearic acid at sn-1 and a hydroxyl group at sn-2 position.

Anwendung

18:0 Lyso PA is suitable for use:

• to determine the extraction recovery of LPA at neutral pH and acidic pH by chromatographic method
• to use as internal standard to study the role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis
• to investigate its effects on clathrin?dependent endocytosis

Biochem./physiol. Wirkung

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA) modulates cell motility, proliferation, invasion, survival and production of growth factors via G protein-coupled receptor (GPCR).

Verpackung

5 mL Amber Glass Screw Cap Vial (857128P-25mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3