810270P
Avanti
C11 TopFluor™ Ceramide-1-Phosphate
N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine-1-phosphate (ammonium salt), powder
Synonym(e):
N-[11-(TopFluor)undecanoyl]-D-ceramide-1-phosphate (ammonium salt)
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About This Item
Empirische Formel (Hill-System):
C42H74BF2N4O6P
CAS-Nummer:
Molekulargewicht:
810.84
UNSPSC-Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
Form
powder
Verpackung
pkg of 1 × 250 μg (810270P-250ug)
Hersteller/Markenname
Avanti Research™ - A Croda Brand 810270P
Versandbedingung
dry ice
Lagertemp.
−20°C
Verwandte Kategorien
Allgemeine Beschreibung
Ceramide-1-phosphate (C1P), an anti-apoptotic lipid is produced with the help of ceramide kinase (CERK) by the direct phosphorylation of ceramide.
The availability of this new fluorescent metabolite provides the researcher with new ways to track cell migration and G protein coupled activity.
Anwendung
C11 TopFluor™ Ceramide-1-Phosphate may be used to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy.
Biochem./physiol. Wirkung
Ceramide-1-phosphate (C1P) is capable of blocking cell death in bone marrow-derived macrophages (BMDMs). It controls the growth and survival in various cell types. C1P bioactive sphingolipid is known to modulate the proliferation and differentiation of photoreceptors. C1P controls apoptosis. It acts as a pro-inflammatory agent and plays a key role in phagocytosis. Ceramide-1-phosphate is well known as a second messenger and an important mediator of inflammatory response.
Verpackung
5 mL Amber Glass Screw Cap Vial (810270P-250ug)
Rechtliche Hinweise
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Ceramide and ceramide 1-phosphate in health and disease
Arana L, et al.
Lipids in Health and Disease, 9(1), 1-12 (2010)
The Role of Ceramide-1-Phosphate in Biological Functions
Handbook of Experimental Pharmacology, 153-153 (2013)
Ceramide-1-Phosphate, a New Mediator of Development and Survival in Retina Photoreceptors
Miranda GE, et al.
Investigative Ophthalmology & Visual Science, 52(9), 6580-6588 (2011)
Ceramide-1-phosphate in cell survival and inflammatory signaling
Gomez MA, et al.
Advances in Experimental Medicine and Biology, 118-130 (2010)
Carolyn M Shirey et al.
Chemistry and physics of lipids, 200, 32-41 (2016-10-26)
Ceramide-1-phosphate (C1P) is an important signaling sphingolipid and a metabolite of ceramide. C1P contains an anionic phosphomonoester head group and has been shown to regulate physiological and pathophysiological processes such as cell proliferation, inflammation, apoptosis, phagocytosis, and macrophage chemotaxis. Despite
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