810262P
Avanti
C11 TopFluor® Ceramide
N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine, powder
Synonym(e):
N-[11-(TopFluor)undecanoyl]-D-erythro-sphingosine
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Alle Fotos(2)
About This Item
Empirische Formel (Hill-System):
C42H70N3O3F2
CAS-Nummer:
Molekulargewicht:
703.02
UNSPSC-Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
Form
powder
Verpackung
pkg of 1 × 250 μg (810262P-250ug)
Hersteller/Markenname
Avanti Polar Lipids 810262P
Versandbedingung
dry ice
Lagertemp.
−20°C
Verwandte Kategorien
Allgemeine Beschreibung
Ceramide, a bioactive sphingolipid belongs to the sphingolipid family of cell lipids. This pore-forming member is insoluble in water. It is a hygroscopic and light sensitive lipid.
Anwendung
C11 TopFluor® Ceramide may be used:
- in the ceramide and B-cell lymphoma-extra-large (Bcl-xL) binding studies to study the effect on ceramide channel formation
- as a tracer in confocal microscopy to treat T84 cells in order to study its localization in sphingomyelinase (SMase)-induced F-actin structures
- to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy
Biochem./physiol. Wirkung
Ceramide is known to participate in apoptosis, mediated by mitochondria. Ceramide channels plays a key role in the onset of apoptosis in vivo.
Verpackung
5 mL Amber Glass Screw Cap Vial (810262P-250ug)
Rechtliche Hinweise
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
Lagerklassenschlüssel
11 - Combustible Solids
Hier finden Sie alle aktuellen Versionen:
Analysenzertifikate (COA)
Lot/Batch Number
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Saslowsky DE, et al.
Molecular Biology of the Cell, 27(7), 1120-1130 (2016)
Ceramide Channels: Destabilization by Bcl-xL and Role in Apoptosis
Chang KT, et al.
Biochimica et Biophysica Acta, 1848(10 0 0), 2374-2374 (2015)
Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility
Kuc N, et al.
Biochemical Pharmacology, 156, 458-466 (2018)
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