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810218C

Avanti

C6-NBD Sphingomyelin

Avanti Research - A Croda Brand 810218C

Synonym(e):

N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sphingosine-1-phosphocholine

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About This Item

Empirische Formel (Hill-System):
C35H61N6O9P
CAS-Nummer:
Molekulargewicht:
740.87
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

Form

liquid

Verpackung

pkg of 1 × 1 mL (810218C-1mg)

Hersteller/Markenname

Avanti Research - A Croda Brand 810218C

Konzentration

1 mg/mL (810218C-1mg)

Versandbedingung

dry ice

Lagertemp.

−20°C

InChI

1S/C35H61N6O9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-21-32(42)30(28-49-51(46,47)48-27-26-41(2,3)4)37-33(43)22-19-17-20-25-36-29-23-24-31(40(44)45)35-34(29)38-50-39-35/h18,21,23-24,30,32,42H,5-17,19-20,22,25-28H2,1-4H3,(H2-,36,37,39,43,46,47)/b21-18+/t30-,32+/m0/s1

InChIKey

YDBDYTGWMRUUSN-PERJAUJZSA-N

Allgemeine Beschreibung

C6-NBD Sphingomyelin is a fluorescent derivative of sphingomyelin. Its fluorescent property is due to presence of NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) group. Sphingomyelin is generally concentrated in the outer leaflet of the plasma membrane.

Anwendung

C6-NBD Sphingomyelin is suitable to study sphingomyelin endocytosis using fluorescence microscopy.

Biochem./physiol. Wirkung

Sphingomyelin (SM) is involved in signal transduction and membrane trafficking. It is synthesized by the transfer of phosphocholine from phosphatidylcholine onto ceramide, catalysed by sphingomyelin synthase on the cell surface and in lumen of the Golgi. SM has high packing density and affinity for sterol which offer a strong barrier to extracellular environment.

Verpackung

5 mL Amber Glass Screw Cap Vial (810218C-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Piktogramme

Skull and crossbonesHealth hazard

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Zielorgane

Central nervous system, Liver,Kidney

WGK

WGK 3


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Die Dokumentenbibliothek aufrufen

Fluorescent and Luminescent Probes for Biological Activity (1999)
Mark L Schultz et al.
BMC medicine, 17(1), 200-200 (2019-11-13)
Niemann-Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body's endogenous cholesterol scavenging particle
Avery L McIntosh et al.
Lipids, 45(6), 465-477 (2010-05-18)
During the last several years, intracellular lipid droplets have become the focus of intense study. No longer an inert bystander, the lipid droplet is now known as a dynamic organelle contributing lipids to many cellular events. However, while the dynamics
Kristin Dauner et al.
The Journal of biological chemistry, 292(14), 5737-5747 (2017-02-16)
The plasma membrane of mammalian cells undergoes constitutive endocytosis, endocytic sorting, and recycling, which delivers nutrients to the lysosomes. The receptors, along with membrane lipids, are normally returned to the plasma membrane to sustain this action. It is not known

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