700022P

7-keto-27-hydroxycholesterol

Avanti Polar Lipids

• Synonym(e): 3β,27-dihydroxy-5-cholesten-7-one
• Empirische Formel (Hill-System): C₂₇H₄₄O₃
• CAS-Nummer: 240129-30-0
• Molekulargewicht: 416.64
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Assay: >99% (TLC)
• Form: powder
• Verpackung: pkg of 1 × 1 mg (700022P-1mg)
• Hersteller/Markenname: Avanti Polar Lipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

7-keto-27-hydroxycholesterol interconversion to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) is catalyzed by hydroxysteroid 11-β dehydrogenase. It is also formed by the oxidation of 7-oxocholesterol (7-OC) in the presence of enzyme by sterol 26-hydroxylase (CYP27A1).

Anwendung

7-keto-27-hydroxycholesterol has been used as an oxysterol compound to study its interaction with smoothened (SMO) protein, as a substrate to 11β-hydroxysteroid dehydrogenases (11β-HSDs) for kinetic measurement studies,

Biochem./physiol. Wirkung

7-keto-27-hydroxycholesterol (7-OC) acts as an agonist for the smoothened (SMO) protein of Hedgehog (Hh) signalling pathway, which is vital for proper cell differentiation in embryonic tissue. It elicits strong affinity to SMO compared to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC). 7-OC is reduced to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) by reactive oxygen species (ROS).

Verpackung

5 mL Amber Glass Screw Cap Vial (700022P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids