G2137

Glycyrrhizinsäure Ammoniumsalz aus glycyrrhiza root (Süßholz)

≥70% (HPLC)

• Synonym(e): 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinsäure Ammoniumsalz
• Lineare Formel: C₄₂H₆₂O₁₆ · NH₃
• CAS-Nummer: 53956-04-0
• Molekulargewicht: 839.96
• Beilstein: 3897076
• EG-Nummer: 258-887-7
• MDL-Nummer: MFCD00167400
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 57654204
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥70% (HPLC)
• Lagertemp.: 2-8°C
• SMILES String: N.CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)C(O)=O
• InChI: 1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1
• InChIKey: ILRKKHJEINIICQ-OOFFSTKBSA-N

Beschreibung

Allgemeine Beschreibung

Glycyrrhizic acid (GA) is a non-selective inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD), which mediates the inter-conversion of active and inactive glucocorticoids. GA also shows inhibitory effect on the cytokine activity of high-mobility group box 1 protein (HMGB1).

Anwendung

The product has been used a source of glycyrrhizic acid (GA), to study its effect on glucose intolerance and insulin resistance in rats fed on high-fat/high-sucrose (HF/HS) diet.

Biochem./physiol. Wirkung

Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319
• P-Sätze: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)