934372

MC-Val-Cit-PAB-PNP

≥95%

• Synonym(e): L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
• Empirische Formel (Hill-System): C₃₅H₄₃N₇O₁₁
• CAS-Nummer: 159857-81-5
• Molekulargewicht: 737.76
• Beilstein: 10322169
• MDL-Nummer: MFCD22200431
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 468592337
• NACRES: NA.22
• Form: powder
• Assay: ≥95%

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Lagertemp.: 2-8°C
• SMILES String: [N+](=O)([O-])c1ccc(cc1)OC(=O)OCc2ccc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)CCCNC(=O)N

Beschreibung

Anwendung

This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).

Leistungsmerkmale und Vorteile

The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the activated carbonate esters can be used for construction of carbamate linkages with amine containing payloads.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable