934291

Thalidomide-O-amido-C₈-NH₂ trifluoroacetate

≥95.0%

• Synonym(e): N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate
• Empirische Formel (Hill-System): C₂₃H₃₀N₄O₆·C₂HF₃O₂
• CAS-Nummer: 1950635-16-1
• Molekulargewicht: 572.53
• UNSPSC-Code: 12352200
• NACRES: NA.21

Eigenschaften

• ligand: thalidomide
• Qualitätsniveau: 100
• Assay: ≥95.0%
• Form: powder or crystals
• Lagertemp.: 2-8°C
• SMILES String: O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]

Beschreibung

Anwendung

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Sonstige Hinweise

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Rechtliche Hinweise

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H312,H360D
• P-Sätze: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Gefahreneinstufungen: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable