930628

VH 032 amide-alkyl C₃-acid

≥95%

• Synonym(e): (4R), (S,R,S)-AHPC-CO-C₃-acid, L-Prolinamide, N-(4-carboxy-1-oxobutyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]
• Empirische Formel (Hill-System): C₂₇H₃₆N₄O₆S
• CAS-Nummer: 2172819-73-5
• Molekulargewicht: 544.66
• MDL-Nummer: MFCD32903592
• UNSPSC-Code: 51471602
• NACRES: NA.21

Eigenschaften

• ligand: VH032
• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Funktionelle Gruppe: carboxylic acid
• Lagertemp.: 2-8°C
• SMILES String: C([C@@H](NC(CCCC(O)=O)=O)C(C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Beschreibung

Anwendung

VH 032 amide-alkyl C₃-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Sonstige Hinweise

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3